Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Cyanophenol | HCID 13019 | — |
| 반응물 | 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14913650 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile | HCID 13713979 | 79.2% |
반응 단계
A mixture of 4-bromoacetyl-5-methyl-2-phenyloxazole (7.0 g), p-cyanophenol (3.0 g), potassium carbonate (6.9 g) and methyl ethyl ketone (100 ml) was heated under reflux for 2 hours. The reaction mixture was concentrated under reduced pressure, and water (100 ml)-ether (100 ml) was added to the residue. The mixture was stirred, and the crystals were collected by filtration. Recrystallization from chloroform-ethanol afforded 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (6.3 g, 78.8%), as brownish prisms, m.p. 202°-203° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04725610 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-b8196817410144b5adfdc7884be60b1f |
| 출처 메모 | uspto-grants-1988_02 |