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Phenylhydrazine → 3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-indole

HRID 441159
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HRID 441159 반응식
[C:1]1([NH:7]N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]([C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=O)=[CH:12][CH:11]=1.CSC1C=CC(C=O)=CC=1.FC1C=CC(CCl)=CC=1>C1(C)C=CC=CC=1.CC(O)=O>[F:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[C:6]3[C:1](=[CH:2][CH:3]=[CH:4][CH:5]=3)[NH:7][C:17]=2[C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[CH:14][CH:15]=1
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참가 물질

6

반응물 4

HCID 7516PhenylhydrazineHCID 96024-Fluorobenzyl chlorideHCID 769854-(Methylthio)benzaldehydeHCID 111970952-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)ethanone

생성물 1

HCID 153373983-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-indole

시약·촉매·용매 1

HCID 18331056
Acetic acid toluene
용매

실험 절차

To phenylhydrazine (50 uL) in toluene-HOAc (2:1, 2 mL) was added 2-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)ethanone (105 mg) (prepared from 4-(methylthio)benzaldehyde and 4-fluorobenzyl chloride by the same method as described in Step 1 of Example 4). After 1 hr at 85° C., the reaction mixture was extracted with EtOAc and HCl. After drying over NaSO4 and evaporation in vacuo the title compound was purified by flash chromatography (67 mg).

후처리

  1. extractionthe reaction mixture was extracted with EtOAc and HCl
  2. dry with materialAfter drying over NaSO4 and evaporation in vacuo the title compound
  3. customwas purified by flash chromatography (67 mg)

출처 및 근거

ORD 기록
ord-7a007ac9cdab40358cecf633ee5e1d0e
출처 데이터셋
uspto-grants-1996_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05521213

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