Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile | HCID 13713979 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile | HCID 54287204 | 92.7% |
반응 단계
Sodium borohydride (0.654 mg) was added to a suspension of 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (5.5 g) in methanol (100 ml)-N,N-dimethylformamide (50 ml), followed by stirring at room temperature for 1 hour. The reaction solution was poured into water and the crystals which separated out were collected by filtration to give 4-[2-hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile (5.1 g, 92.7%). Recrystallization from acetone afforded colorless neddles, m.p. 176°-177° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04725610 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-2f9a930e708d48b38d38a3a790caddee |
| 출처 메모 | uspto-grants-1988_02 |