2-Nitroaniline → Benzamide, 4-nitro-N-(2-nitrophenyl)-

HRID 441227노트

반응식

HRID 441227 반응식
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].C(N(CC)CC)C.[N+:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1)([O-:20])=[O:19]>ClCCl>[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH:6][C:25](=[O:26])[C:24]1[CH:23]=[CH:22][C:21]([N+:18]([O-:20])=[O:19])=[CH:29][CH:28]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 69462-NitroanilineHCID 8471TriethylamineHCID 85024-Nitrobenzoyl chloride

생성물 1

HCID 5155676Benzamide, 4-nitro-N-(2-nitrophenyl)-수율 63.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 2-nitroaniline (1.38 g) and triethylamine (1.67 ml) in dichloromethane (30 ml) were added 4-nitrobenzoyl chloride (1.85 g) and the solution was stirred at ambient temperature for 4 hours. The solution was washed successively with 1N hydrochloric acid, saturated aqueous sodium hydrogencarbonate, water and brine, and the organic layer was dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was solidified with n-hexane to give 2-nitro-N-(4nitrobenzoyl)aniline (1.82 g).

후처리

  1. washThe solution was washed successively with 1N hydrochloric acid, saturated aqueous sodium hydrogencarbonate, water and brine
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-884c8b27e2124b9c80f5c99e079dfec6
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521170

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