Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-{4-[2-(1-Pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Diphenyl chlorophosphate | HCID 75654 | — |
| 반응물 | 2-(1H-pyrrol-1-yl)benzoic acid | HCID 728521 | — |
| 반응물 | (4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | HCID 2984117 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-{4-[2-(1-Pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline | HCID 10598275 | 60.5% |
반응 단계
To a solution of 2-(1-pyrrolyl)benzoic acid (206 mg), diphenyl chlorophosphate (325 mg), 1-(4-aminobenzoyl}-1,2,3,4-tetrahydroquinoline (277 mg) in tetrahydrofuran (10 ml) was added triethylamine (333 mg) at 0° C. The resulting mixture was allowed to warm to ambient temperature where it was maintained for 5 hours. The solvent was evaporated and diluted with ethyl acetate and washed with water, saturated sodium bicarbonate aqueous solution and brine. The organic layer was dried over sodium sulfate and concentrated to give 1-{4-[2-(1-pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline (280 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05521170 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-b85ecc7cd5d44739bc7c54ad7db59d8c |
| 출처 메모 | uspto-grants-1996_05 |