Diketene → m-Propionamido-acetylacetanilide

HRID 441274노트

반응식

HRID 441274 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[NH:11][C:12](=[O:15])[CH2:13][CH3:14]>C1C=CC=CC=1>[C:12]([NH:11][C:10]1[CH:9]=[C:8]([CH:18]=[CH:17][CH:16]=1)[NH:7][C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1])(=[O:15])[CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 12661DiketeneHCID 89953N-(3-Aminophenyl)propanamide

생성물 1

HCID 21419827m-Propionamido-acetylacetanilide수율 95.1%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

42 g of diketene were added to a solution of 82.1 g of m-aminopropionanilide in 400 ml of benzene and the mixture was stirred for 41/2 hours and then was vacuum filtered. The recovered precipitate was washed with benzene, then isopropyl ether and dried to obtain 118 g of m-propionamido-acetylacetanilide melting at 70° C. which was used as is for the next step.

후처리

  1. filtrationfiltered
  2. washThe recovered precipitate was washed with benzene
  3. dry with materialisopropyl ether and dried

출처 및 근거

ORD 기록
ord-549f179fa804483996fb523fc0bbcdac
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04039316

반응 노트

불러오는 중…