Water → 2-(Phenylsulfonyl)-methyl-benzoxazole

HRID 441288

반응식

HRID 441288 반응식
ClC[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[C:12]1([S:18]([O-:21])(=O)=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Na+].O.[CH3:24]N(C=O)C>>[C:12]1([S:18]([C:3]2[O:4][C:5]3[CH:11]=[CH:10][CH:9]=[C:8]([CH3:24])[C:6]=3[N:7]=2)(=[O:21])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 517327Sodium benzenesulfonateHCID 20619892-(Chloromethyl)-1,3-benzoxazole

생성물 1

HCID 214202942-(Phenylsulfonyl)-methyl-benzoxazole

반응 조건

온도
70 °C

실험 절차

33 g (0.2 mole) of 2-chloromethylbenzoxazole and 32.8 g of sodium benzene sulfonate were dissolved in 200 ml of DMF, heated within one-half hour to 70° C., for 1 hour at 70° C., for 1 hour to 80° C. and for 1 hour to 90° C., and after cooling, allowed to flow into 300 ml of H2O, while stirring well. The reaction mixture was filtered with suction, washed well with H2O and dried. 48.8 g (98.4 % of the theory) were obtained. After recrystallization from ethanol, 41 g of colorless cristals melting at 108° to 109° C. were obtained. ##STR28##

후처리

  1. temperatureafter cooling
  2. filtrationThe reaction mixture was filtered with suction
  3. washwashed well with H2O
  4. customdried
  5. custom48.8 g (98.4 % of the theory) were obtained
  6. customAfter recrystallization from ethanol, 41 g of colorless cristals melting at 108° to 109° C.
  7. customwere obtained

출처 및 근거

ORD 기록
ord-0ad286eaae8b46f0800b2c86bbd93a75
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04039531

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