1-Bromodecane → 2-(Decylthio)ethanol

HRID 44138

반응식

HRID 44138 반응식
[C:1](=[O:4])([O-])[O-].[K+].[K+].[CH2:7](Br)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[SH:18][CH:19](O)C>CC(C)=O>[CH2:7]([S:18][CH2:19][CH2:1][OH:4])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 81731-BromodecaneHCID 11430Potassium CarbonateHCID 4713212Mercapto-ethanol

생성물 1

HCID 966542-(Decylthio)ethanol수율 94%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Under nitrogen, to a suspension of potassium carbonate (27 g, 200 mmol) in acetone (100 ml) was added decyl bromide (10 ml, 50 mmol) and mercaptoethanol (4.4 ml, 63 mmol). The suspension was stirred at room temperature for 2 days, then partitioned between water and 80% hexane/ethyl acetate. The organic phase was washed with 2N sodium hydroxide, dried over magnesium sulfate, and the volatiles removed under vacuum to give 2-(decylthio)ethanol (10.2 g, 47 mmol) as a colorless liquid that was used without further purification.

후처리

  1. custompartitioned between water and 80% hexane/ethyl acetate
  2. washThe organic phase was washed with 2N sodium hydroxide
  3. dry with materialdried over magnesium sulfate
  4. customthe volatiles removed under vacuum

출처 및 근거

ORD 기록
ord-6efcb7dbfc704283b8e90c0546e2fa38
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541375B2

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