Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-[2-(4-Hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| 반응물 | 2-(2-Tosyloxyethyl)-2,3-dihydrobenzofuran | HCID 54469994 | — |
| 용매 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 생성물 | 2-[2-(4-Hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran | HCID 21331966 | — |
반응 단계
The mixture of 4.6 g of 2-(2-tosyloxyethyl)-2,3-dihydrobenzofuran, 2.64 g of 4-hydroxy-4-phenylpiperidine, 10 g of anhydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is relfuxed for 48 hours. It is filtered, evaporated and the residue recrystallized from isopropanol-petroleum ether, to yield the 2-[2-(4-hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran melting at 107°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04039676 |
| 출처 데이터셋 | uspto-grants-1977_08 |
| ORD ID | ord-eaadb055c411437da796978a45fc7ac1 |
| 출처 메모 | uspto-grants-1977_08 |