Morpholine → 4-(3-Chloropyrazin-2-YL)morpholine

HRID 441729

반응식

HRID 441729 반응식
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CN(C)C=O>[Cl:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][N:6]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 785752,3-Dichloropyrazine

생성물 1

HCID 205289944-(3-Chloropyrazin-2-YL)morpholine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,3-dichloropyrazine (5 g., 0.034 mmole), morpholine (5.8 g., 0.067 mmole), and 50 ml. of dimethylformamide are heated at 90°-120° C. for 6-14 hours, in an atmosphere of nitrogen. The reaction mixture is cooled and evaporated to dryness at a water-bath temperature of 55° C. A chloroform solution of the residue is extracted twice with 0.1M sodium hydroxide, dried over magnesium sulfate and evaporated to leave the product.

후처리

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness at a water-bath temperature of 55° C
  3. extractionA chloroform solution of the residue is extracted twice with 0.1M sodium hydroxide
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customto leave the product

출처 및 근거

ORD 기록
ord-c4676298a1bb4cf5b68cda20689a6741
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042586

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