(p-Chlorophenyl)trmethylsilane → HCID 21417831, 화합물

HRID 441797노트

반응식

HRID 441797 반응식
C[Si](C)(C)C1C=CC(Cl)=CC=1.[Mg].CNC1C=CC=CC=1C=O.[CH3:23][NH:24][C:25]1[CH:42]=[CH:41][C:28]([CH:29]([OH:40])[C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:39])([CH3:38])[CH3:37])=[CH:32][CH:31]=2)=[CH:27][CH:26]=1>N1C=CC=CC=1.O>[CH3:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([CH:29]([OH:40])[C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:37])([CH3:39])[CH3:38])=[CH:32][CH:31]=2)=[CH:41][CH:42]=1.[CH3:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:29]([C:30]2[CH:35]=[CH:34][C:33]([Si:36]([CH3:38])([CH3:37])[CH3:39])=[CH:32][CH:31]=2)=[O:40])=[CH:41][CH:42]=1

참가 물질

8

반응물 4

HCID 66351(p-Chlorophenyl)trmethylsilaneHCID 2675692-(methylamino)benzaldehydeHCID 5462224MagnesiumHCID 21417831HCID 21417831, 화합물

생성물 2

HCID 21417831HCID 21417831, 화합물HCID 21417851HCID 21417851, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 1049Pyridine용매2회

실험 절차

4-Methylamino-4'-trimethylsilylbenzhydrol was prepared by a Grignard reagent formulated from 0.2 mole of 4-trimethylsilylchlorobenzene and 0.2 mole of magnesium with 0.2 mole of N-methylaminobenzaldehyde. 0.4 mole of the thus obtained 4-methylamino-4'-trimethylsilylbenzhydrol was dissolved in pyridine, and to the resultant solution was added, dropwise over a period of 40 hours at room temperature, an oxidizing agent prepared by adding 125 ml of pyridine to a solution of 7.5 ml of water and 12.5 mole of chromic anhydride under agitation while being cooled with water. The reaction product was refined by chromatography using silica gel, to obtain 41 g of 4-methylamino-4'-trimethylsilyl benzophenone in a yield of 38%.

후처리

  1. customan oxidizing agent prepared

출처 및 근거

ORD 기록
ord-ec764d0c43b74074811fa9878085baf4
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042613

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