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Water → 2-Isopropyl 4-methylpent-4 enoic acid, alpha-cyano-3 phenoxybenzyl ester

HRID 441842
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HRID 441842 반응식
[CH:1]([CH:4]([CH2:8][C:9]([CH3:11])=[CH2:10])[C:5]([OH:7])=[O:6])([CH3:3])[CH3:2].[C:12]([CH:14](Br)[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:16]=1)#[N:13].C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O>[CH:1]([CH:4]([CH2:8][C:9]([CH3:11])=[CH2:10])[C:5]([O:7][CH:14]([C:12]#[N:13])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:16]=1)=[O:6])([CH3:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 12713810alpha-Cyano-3-phenoxybenzyl bromideHCID 149108594-Methyl-2-propan-2-ylpent-4-enoic acid

생성물 1

HCID 1317108682-Isopropyl 4-methylpent-4 enoic acid, alpha-cyano-3 phenoxybenzyl ester

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

A mixture of 2-isopropyl-4-methylpent-4-enoic acid (1.0g), alpha-cyano-3-phenoxybenzyl bromide (1.9g) and potassium carbonate (1.0g) in anhydrous acetone (40ml) was stirred at room temperature for 4 hours. Water was added to the reaction mixture and the product extracted with ether, the ethereal extracts washed with water (X2) and dried over magnesium sulphate. Evaporation of the solvent gave a crude product which was purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent to give the desired ester. R.I. nD20 1.5343.

후처리

  1. extractionthe product extracted with ether
  2. washthe ethereal extracts washed with water (X2)
  3. dry with materialdried over magnesium sulphate
  4. customEvaporation of the solvent
  5. customgave a crude product which
  6. customwas purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent

출처 및 근거

ORD 기록
ord-36732275e3d3415d9b09f797ba180afb
출처 데이터셋
uspto-grants-1977_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04042710

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