Chloroacetyl chloride → N-(4-bromo-2-nitrophenyl)-2-chloroacetamide

HRID 44185

반응식

HRID 44185 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15]>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:14](=[O:15])[CH2:13][Cl:12])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 701324-Bromo-2-nitroaniline

생성물 1

HCID 16457083N-(4-bromo-2-nitrophenyl)-2-chloroacetamide수율 96%

실험 절차

To a solution of 4-bromo-2-nitroaniline (15.0 g, 69.1 mmol) was added drop wise 2-chloroacetyl chloride (9.4 g, 82.9 mmol) under nitrogen. After refluxing for 1.5 h, the reaction mixture was cooled to ambient temperature and the solvent was removed under reduced pressure. Crystallization from ethyl acetate/hexane afforded N-(4-bromo-2-nitrophenyl)-2-chloroacetamide (19.4 g, 66.1 mmol, 96%) as yellow needles.

후처리

  1. temperatureAfter refluxing for 1.5 h
  2. customthe solvent was removed under reduced pressure
  3. customCrystallization from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-ffe1c224bf7a4abdb0904482ad6ae5ce
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541404B2

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