Piperidine → Ethyl 2-methyl-4-piperidinobutyrate

HRID 441879

반응식

HRID 441879 반응식
Br[CH2:2][CH2:3][CH:4]([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1C=CC=CC=1>[CH3:10][CH:4]([CH2:3][CH2:2][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 12780980Ethyl 4-bromo-2-methylbutanoate

생성물 1

HCID 20361120Ethyl 2-methyl-4-piperidinobutyrate

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
60 °C

실험 절차

10.5 g. (0.05 mole) of ethyl γ-bromo-α-methylbutyrate was combined with 17.0 g. (0.20 mole) of piperidine and 100 ml. of benzene and stirred for 16 hours at room temperature and heated at 60° C. for 4 hours. The reaction mixture was cooled and the colorless solid which appeared was removed by filtration. The mother liquor was concentrated to give ethyl α-methyl-γ-piperidinobutyrate as a mobile yellow liquid which distilled (b.p. 78° C. at 0.25 mm.) as 6.7 g. (63%) of colorless liquid. The nuclear magnetic resonance and infrared spectra were consistent with the desired compound.

후처리

  1. temperatureThe reaction mixture was cooled
  2. customthe colorless solid which appeared was removed by filtration
  3. concentrationThe mother liquor was concentrated

출처 및 근거

ORD 기록
ord-5285d10f4538403f9ea38ebefec88d98
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042694

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