Dicyclohexylcarbodiimide → 5,5-Dimethyl-10-[4-(pyrrolidino)butyryloxy]-2-phenethyl-8-(2-tetradecyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 441885노트

반응식

HRID 441885 반응식
[CH3:1][C:2]1([CH3:39])[C:26]2[CH2:27][CH2:28][N:29]([CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:30][C:25]=2[C:5]2[C:6]([OH:24])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:40].[N:41]1([CH2:46][CH2:47][CH2:48][C:49](O)=[O:50])[CH2:45][CH2:44][CH2:43][CH2:42]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:40].[CH3:39][C:2]1([CH3:1])[C:26]2[CH2:27][CH2:28][N:29]([CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:30][C:25]=2[C:5]2[C:6]([O:24][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][N:41]3[CH2:45][CH2:44][CH2:43][CH2:42]3)=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1

참가 물질

4

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 148556824-(Pyrrolidin-1-yl)butanoic acid hydrochlorideHCID 214181165,5-Dimethyl-10-hydroxy-2-phenethyl-8-(2-tetradecyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine

생성물 1

HCID 214181495,5-Dimethyl-10-[4-(pyrrolidino)butyryloxy]-2-phenethyl-8-(2-tetradecyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

실험 절차

5,5-Dimethyl-10-hydroxy-2-phenethyl-8-(2-tetradecyl)-1,2,3,4-tetrahydro-5H-[ 1]benzopyrano[3,4-d]pyridine, γ-pyrrolidinobutyric acid hydrochloride and dicyclohexylcarbodiimide are reacted in equimolar amounts according to Example 1 to produce the desired product.

출처 및 근거

ORD 기록
ord-dd22514682b94b439e09aa456bd562b5
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042694

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