Benzene → 2-[1-Allyl-3-(5-methylsulfonyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde

HRID 441914노트

반응식

HRID 441914 반응식
[CH3:1][S:2]([C:5]1[S:9][C:8]([N:10]=[C:11]=[O:12])=[N:7][N:6]=1)(=[O:4])=[O:3].C([CH:16]([NH2:19])[CH:17]=[O:18])C=C.[CH:20]1[CH:25]=CC=C[CH:21]=1>>[CH2:25]([N:19]([CH2:16][CH:17]=[O:18])[C:11]([NH:10][C:8]1[S:9][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[N:6][N:7]=1)=[O:12])[CH:20]=[CH2:21]

참가 물질

4

반응물 3

HCID 241Benzene2회HCID 542537365-Methylsulfonyl-1,3,4-thiadiazol-2-yl isocyanateHCID 571017922-Allyl-aminoacetaldehyde

생성물 1

HCID 203927052-[1-Allyl-3-(5-methylsulfonyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde

실험 절차

A mixture of 5-methylsulfonyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the dimethyl acetal of 2-allyl-aminoacetaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 15 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. The residue is then recrystallized to yield the desired product the dimethyl acetal of 2-[1-allyl-3-(5-methylsulfonyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for a period of about 15 minutes
  5. customto yield a solid product as the residue
  6. customThe residue is then recrystallized

출처 및 근거

ORD 기록
ord-550700e25f424bcea7950a90db612af8
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04043795

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