2-(2-Methoxyethyl)-2-imidazoline hydrochloride → 2-(2-Methoxyethyl)-4,5-dihydro-1H-imidazole

반응식

Cl.[Na].Cl.[CH3:4][O:5][CH2:6][CH2:7][C:8]1[NH:9][CH2:10][CH2:11][N:12]=1>>[CH3:4][O:5][CH2:6][CH2:7][C:8]1[NH:12][CH2:11][CH2:10][N:9]=1

참가 물질

반응물 2

HCID 227560362-(2-Methoxyethyl)-2-imidazoline hydrochloride

HCID 23872008Sodium hydrochloride

생성물 1

HCID 227560372-(2-Methoxyethyl)-4,5-dihydro-1H-imidazole

실험 절차

100 Parts of 6N sodium hydrochloride in a suitable reaction vessel are cooled to 5° C. with an ice-water bath and 22.7 parts of the 2- (2-methoxyethyl)-2 -imidazoline hydrochloride of Example 2 are added to the cold solution. An oil separates. The contents of the vessel are transferred to a separatory vessel and the aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran. The combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours. The potassium carbonate is then filtered off and the tetrahydrofuran solution is distilled to yield 14.0 parts of 2-(2-methoxyethyl)-2-imidazoline.

후처리

customThe contents of the vessel are transferred to a separatory vessel
extractionthe aqueous phase is extracted four times with 30 parts of reagent grade tetrahydrofuran
dry with materialThe combined tetrahydrofuran extracts are dried over anhydrous potassium carbonate for 15 hours
filtrationThe potassium carbonate is then filtered off
distillationthe tetrahydrofuran solution is distilled

출처 및 근거

ORD 기록: ord-c93b7bb8442f4414953331ce66376efe
출처 데이터셋: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04044009

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