Ethyl 2-aminoquinoline-3-carboxylate → Ethyl 3,4-dihydro-4-oxopyrimido(4,5-b)quinoline-2-carboxylate

HRID 442198

반응식

HRID 442198 반응식
[C:1]([C:6](=[NH:8])[O-])([O:3][CH2:4][CH3:5])=[O:2].[NH2:9][C:10]1[C:19]([C:20](OCC)=[O:21])=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>C(O)C>[N:9]1[C:10]2=[N:11][C:12]3[C:17]([CH:18]=[C:19]2[C:20](=[O:21])[NH:8][C:6]=1[C:1]([O:3][CH2:4][CH3:5])=[O:2])=[CH:16][CH:15]=[CH:14][CH:13]=3

참가 물질

4

반응물 2

HCID 283477Ethyl 2-aminoquinoline-3-carboxylateHCID 227528221-Carbethoxyformimidate

생성물 1

HCID 135765023Ethyl 3,4-dihydro-4-oxopyrimido(4,5-b)quinoline-2-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The same compound is obtained by: (a) refluxing equimolar amounts of 1-carbethoxyformimidate and ethyl 2-aminoquinoline-3-carboxylate in ethanol for 3 hours. The reaction mixture is concentrated, the product collected by filtration and recrystallized from hot chloroform; or (b) refluxing equimolar amounts of 1-carbethoxyformamidine and 2-aminoquinoline-3-carboxamide in ethanol for 3-4 hours in the presence of an equimolar amount of sodium ethoxide. The reaction mixture is worked up as described in (a) above.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. filtrationthe product collected by filtration
  3. customrecrystallized from hot chloroform
  4. temperatureor (b) refluxing equimolar amounts of 1-carbethoxyformamidine and 2-aminoquinoline-3-carboxamide in ethanol for 3-4 hours in the presence of an equimolar amount of sodium ethoxide

출처 및 근거

ORD 기록
ord-0de48ff5924342b4a28a9dc891b6be5d
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04044134

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