Ethyl oxamate → HCID 135705331, 화합물

HRID 442213노트

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HRID 442213 반응식
[NH2:1][C:2]1[C:11]([C:12]([NH2:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:15](OCC)(=O)[C:16]([NH2:18])=[O:17].C[O-].[Na+]>C(O)CO>[N:1]1[C:2]2=[N:3][C:4]3[C:9]([CH:10]=[C:11]2[C:12](=[O:13])[NH:14][C:15]=1[C:16]([NH2:18])=[O:17])=[CH:8][CH:7]=[CH:6][CH:5]=3

참가 물질

5

반응물 3

HCID 69238Ethyl oxamateHCID 52002282-Amino-3-quinolinecarboxamideHCID 10942334Sodium Methoxide

생성물 1

HCID 135705331HCID 135705331, 화합물

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

반응 조건

온도
170 °C

실험 절차

A mixture of 2-aminoquinoline-3-carboxamide (2.0 g., 1.15 millimoles) ethyl oxamate (2.71 g., 23.1 millimoles), ethylene glycol (10 ml.) and sodium methoxide (10 mg.) is heated at 170° C. for 1 hour. The product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture followed by chilling in an ice bath. It is filtered off, washed with cold methanol and dried in vacuo. Yield = 0.768 g. (28%). M.P. 320° C.

후처리

  1. customThe product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture
  2. temperatureby chilling in an ice bath
  3. filtrationIt is filtered off
  4. washwashed with cold methanol
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-55ac4ce680434f528859486b19e42471
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04044134

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