1,3-Dibromopropane → N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane

HRID 442222노트

반응식

HRID 442222 반응식
[C:1](=[O:4])([O-])[O-].[K+].[K+].[CH3:7][NH:8][CH2:9][CH2:10][CH2:11][OH:12].Br[CH2:14][CH2:15][CH2:16]Br>C(O)C>[CH3:7][N:8]([CH2:9][CH2:10][CH2:1][OH:4])[CH2:14][CH2:15][CH2:16][N:8]([CH3:7])[CH2:9][CH2:10][CH2:11][OH:12]

참가 물질

5

반응물 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 101489863-(Methylamino)-1-propanol

생성물 1

HCID 12721803N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane수율 55.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

15 g of anhydrous potassium carbonate are added to a solution of 9 g of 3-methylaminopropanol and 10 g of 1,3-dibromopropane in 100 ml of ethanol, and the reaction mixture is stirred and refluxed for 24 hours. The mixture is allowed to cool, filtered, the filtrate is evaporated, and the residue is distilled. 6 g of N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane are obtained; b.p.: 150°-154° C/2 mmHg, nD20 = 1.4793.

후처리

  1. temperaturerefluxed for 24 hours
  2. temperatureto cool
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-b6f9df485a2c4b1e8434697c003d3d95
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04044146

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