4'-Fluoro-2'-methoxy-4-nitrobiphenyl → 4'-Fluoro-2'-methoxy[1,1'-biphenyl]-4-amine
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[C:4]([O:17][CH3:18])[CH:3]=1.[H][H]>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[C:4]([O:17][CH3:18])[CH:3]=1참가 물질
5
실험 절차
A mixture of 10 grams of 4'-fluoro-2'-methoxy-4-nitrobiphenyl in 250 ml. of ethanol is reduced by hydrogen at atmospheric pressure and at room temperature using 5% palladium-on-charcoal (0.5 gram) catalyst. After the required uptake of hydrogen, the mixture is filtered and the catalyst washed with fresh ethanol. The ethanol solution is then concentrated in vacuo, and the residue recrystallized from aqueous ethanol to yield 4-(4'-fluoro-2'-methoxyphenyl)-aniline.
후처리
- filtrationAfter the required uptake of hydrogen, the mixture is filtered
- washthe catalyst washed with fresh ethanol
- concentrationThe ethanol solution is then concentrated in vacuo
- customthe residue recrystallized from aqueous ethanol
출처 및 근거
- ORD 기록
- ord-b68a5fb89a654044a40c3a10d2f81774
- 출처 데이터셋
- uspto-grants-1977_08
- 특허 번호
- US04044049
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