Ammonia → 4'-Fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

반응식

C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:7]=[CH:6][C:5]=1[OH:17].[NH3:19]>>[OH:17][C:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:9][C:4]=1[C:3]([NH2:19])=[O:2]

참가 물질

반응물 2

HCID 222Ammonia2회

HCID 21416429Methyl 4'-fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylate

생성물 1

HCID 214164704'-Fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

실험 절차

A mixture of 5.3 grams of methyl-2-hydroxy-5-(4'-fluorophenyl)-benzoate and 20 ml. of liquid ammonia is reacted in a bomb at 100° C. for 4 hours. After cooling the bomb is opened and the ammonia allowed to evaporate. The residue is then recrystallized from benzene to yield 2-hydroxy-5-(4'-fluorophenyl)-benzamide (m.p. 206° - 207° C.).

후처리

temperatureAfter cooling the bomb
customto evaporate
customThe residue is then recrystallized from benzene

출처 및 근거

ORD 기록: ord-82e3831daaf14367b10a16b9af5ae4c5
출처 데이터셋: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04044049

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