Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → palmitoyl-L-Ala-D-Glu(OSu)OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 반응물 | palmitoyl-L-Ala-D-Glu(OH)OBzl | HCID 131714154 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | palmitoyl-L-Ala-D-Glu(OSu)OBzl | HCID 131714153 | 7,846.1% |
반응 단계
To a solution of palmitoyl-L-Ala-D-Glu(OH)OBzl (1)(1.84 g) in a mixture of tetrahydrofuran (20 ml) and chloroform (30 ml) were added N-hydroxysuccinimide (425 mg) and dicyclohexylcarbodiimide (728 mg). The reaction mixture was kept for 18 hours at room temperature and the precipitate was filtered off and washed with chloroform. The filtrate was concentrated in vacuo and the diisopropylether was added to the residue. The product was collected and dried to afford palmitoyl-L-Ala-D-Glu(OSu)OBzl (2)(170 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04725582 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-34b5a02bca8a409287c4f086e8e5d348 |
| 출처 메모 | uspto-grants-1988_02 |