Phosgene → 5-Fluorobenzothiazol-2-yl isocyanate
반응식
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[F:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=1참가 물질
4
실험 절차
A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-5-fluorobenzothiazole (0.1 mole) is added with stirring. After the addition is completed, the reaction mixture is heated at reflux for a period of about one hour. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 5-fluorobenzothiazol-2-yl isocyanate dimer.
후처리
- customequipped with a mechanical stirrer
- temperaturethermometer and reflux condenser
- additionAfter the addition
- temperaturethe reaction mixture is heated
- temperatureat reflux for a period of about one hour
- temperatureAfter this time the mixture is cooled
- customthe solid product formed
- filtrationis recovered by filtration
- customThe solid is then dried
출처 및 근거
- ORD 기록
- ord-950a8e3837444a0eb9cfaae8ed81bc96
- 출처 데이터셋
- uspto-grants-1977_08
- 특허 번호
- US04045446
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