Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Phenyl-4-piperidinecarboxamide → 8-methoxy-5-methyl-11-(1-methyl-4-piperidyl)-5H-dibenzo[b,e]-[1,4]diazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Phenyl-4-piperidinecarboxamide | HCID 590499 | — |
| 반응물 | 5'-methoxy-1-methyl-2'-(N-methylanilino)isonipecotanilide | HCID 21414379 | — |
| 반응물 | Phosphorus pentoxide phosphorus oxychloride | HCID 131710870 | — |
| 생성물 | 8-methoxy-5-methyl-11-(1-methyl-4-piperidyl)-5H-dibenzo[b,e]-[1,4]diazepine | HCID 21414392 | — |
반응 단계
The general procedures of Examples 1 and 2 are repeated. The compound 4-methoxy-N-methyl-2-nitrodiphenylamine is prepared and reduced to the corresponding 2-amino derivative which is converted to 5'-methoxy-1-methyl-2'-(N-methylanilino)isonipecotanilide. This isonipecotanilide base is treated with phosphorus pentoxide/phosphorus oxychloride, the cyclized product is isolated and purified and 8-methoxy-5-methyl-11-(1-methyl-4-piperidyl)-5H-dibenzo[b,e]-[1,4]diazepine is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04045445 |
| 출처 데이터셋 | uspto-grants-1977_08 |
| ORD ID | ord-4a5e4016d0d347c8b65ac4d11484419d |
| 출처 메모 | uspto-grants-1977_08 |