Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 1-(4-Morpholin-4-ylmethyl-1H-pyrrol-2-yl)-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 2-Acetylpyrrole | HCID 14079 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(4-Morpholin-4-ylmethyl-1H-pyrrol-2-yl)-ethanone | HCID 66636007 | — |
반응 단계
To a solution of morpholine (22 mmoles) in acetic acid (60 ml) at 0° C. there are added 1-(1H-pyrrol-2-yl)-ethanone (20 mmoles) and formaldehyde (20 mmoles) 37% in water. The reaction mixture is stirred overnight at ambient temperature. At 0° C., the solution is brought to alkaline pH (10-12) using 20% aqueous NaOH solution and is then extracted with DCM. The organic phase is washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness. Purification by flash chromatography on silica gel (SiO2; gradient DCM/MeOH) to yield the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541412B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-a85c8460d2724fbe85f1a9c59865968b |
| 출처 메모 | uspto-grants-2013_09 |