Triethylamine → HCID 21415057, 화합물

HRID 442479노트

반응식

HRID 442479 반응식
Cl.Cl.[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[CH2:6][CH2:5]1.C(N(CC)CC)C.Cl[CH2:29][C:30]([NH:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31]>CN(C)C=O>[NH:32]([C:30]([CH2:29][NH:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:14])[CH2:6][CH2:5]1)=[O:31])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

참가 물질

5

반응물 3

HCID 8471Triethylamine2회HCID 11485ChloroacetanilideHCID 227548374-Amino-1-(4-phenyl-4-oxobutyl)piperidine dihydrochloride

생성물 1

HCID 21415057HCID 21415057, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Amino -1-(4-phenyl-4-oxobutyl) piperidine dihydrochloride (1.75g) was suspended in dimethylformamide (15 ml) containing triethylamine (3 ml) and chloroacetanilide (0.85G) added. The mixture was stirred for 48 hours and the precipitate of Et3N.HC1 filtered off. The filtrate was poured into water and the solid product filtered off and recrystallised from EtOH/H2O to give the title compound (1.35g). This was converted to the hydrochloride (1.35g) by treatment with EtOH-HC1 and Et2O, m.p. 255.1°.

후처리

  1. additionadded
  2. filtrationHC1 filtered off
  3. additionThe filtrate was poured into water
  4. filtrationthe solid product filtered off
  5. customrecrystallised from EtOH/H2O

출처 및 근거

ORD 기록
ord-10d16e777b1242f892b6b2ef833ada11
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045566

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