Diisopropylamine → Diisopropylammonium 2-propyl-5-thiazolecarboxylate

HRID 442494

반응식

HRID 442494 반응식
[CH2:1]([C:4]1[S:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][N:8]=1)[CH2:2][CH3:3].[CH:12]([NH:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]>CC(C)=O>[CH2:1]([C:4]1[S:5][C:6]([C:9]([O-:11])=[O:10])=[CH:7][N:8]=1)[CH2:2][CH3:3].[CH:12]([NH2+:15][CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13]

참가 물질

4

반응물 2

HCID 7912DiisopropylamineHCID 65773Tizoprolic Acid

생성물 1

HCID 21415066Diisopropylammonium 2-propyl-5-thiazolecarboxylate수율 90%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4.45 Grams of 2-propyl-5-thiazolecarboxylic acid (obtained in Example II) are dissolved in 120 cc of acetone and 2.62 gm of diisopropylamine are added. The solvent is evaporated off under low pressure and the crystals thus obtained are recrystallized from isopropyl ether. The diisopropylammonium 2-propyl-5-thiazolecarboxylate is obtained in the form of colorless crystals, soluble in water and in alcohol, melting at 120° C. (Yield: 90%).

후처리

  1. customThe solvent is evaporated off under low pressure
  2. customthe crystals thus obtained
  3. customare recrystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-378c935309a3447ca2cda4daca4c765c
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045567

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