Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethyl Isothiocyanate → 1-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethyl Isothiocyanate | HCID 16741 | — |
| 반응물 | Benzenemethanol,2-(aminomethyl)-5-chloro-a-phenyl- | HCID 12241006 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea | HCID 21415460 | — |
반응 단계
2-aminomethyl-5-chlorobenzhydrol (10 g; 0.04 mole) in 100 ml methanol and 2 ml triethylamine was treated dropwise with a solution of phenethyl isothiocyanate (8.6 g; 0.053 mole) in 25 ml of methanol. After 16 hours at room temperature the reaction mixture was evaporated and the residue was extracted with petroleum ether. The residual oil was recrystallized from diisopropyl ether to yield 1-(4-chloro-2-(α-hydroxybenzyl)benzyl)-3-phenethylthiourea as a white powder (M.Pt. 97° -- 101° ).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04045572 |
| 출처 데이터셋 | uspto-grants-1977_08 |
| ORD ID | ord-93903d4497c1482bb535b4bb2fd9bcc5 |
| 출처 메모 | uspto-grants-1977_08 |