Imidazole → 2,4-Dichloro-beta-(1-imidazolyl)propiophenone

HRID 442508노트

반응식

HRID 442508 반응식
C(C(C1C=[CH:9][C:8]([Cl:11])=[CH:7]C=1Cl)=O)=C.[Cl:13][C:14]1[CH:19]=C(Cl)C=CC=1C(C=C)O.Br[C:26]1[C:27](=O)[C:28](Br)=[CH:29][C:30](Br)(Br)[CH:31]=1.[NH:36]1C=C[N:38]=[CH:37]1.CC[O:43]CC>>[Cl:11][CH:8]([CH2:7][N:36]1[CH:19]=[C:14]([Cl:13])[N:38]=[CH:37]1)[C:9]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:43]

참가 물질

6

반응물 5

HCID 795ImidazoleHCID 3283Diethyl EtherHCID 884332,4,4,6-Tetrabromocyclohexa-2,5-dienoneHCID 202826161-(2,4-Dichlorophenyl)prop-2-en-1-olHCID 202826771-(2,4-Dichlorophenyl)prop-2-en-1-one

생성물 1

HCID 536940332,4-Dichloro-beta-(1-imidazolyl)propiophenone

실험 절차

7.0 g. of 2,4-dichlorophenyl vinyl ketone (prepared by Jones oxidation of 2,4-dichlorophenyl vinyl carbinol using the general method described in J. Chem. Soc. (C), 1966, p. 1972) in 350 ml. of anhydrous ether was treated with 3.5 g. of imidazole, the solution stirred overnight and then washed with water (3 × 30 ml.). The solution is dried (MgSO4) and evaporated to give 2,4-dichloro-β-(1-imidazolyl)propiophenone as an amber gum (8.65 g.). The hydrochloride salt may be precipitated from ether and recrystallized from methanol/acetone as colorless rods, m.p. 105.5°-110° C.

후처리

  1. washwashed with water (3 × 30 ml.)
  2. dry with materialThe solution is dried (MgSO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-2b1a10289aac4060948347073ffdb68f
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045568

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