Imidazole → 1-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

HRID 442509노트

반응식

HRID 442509 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[CH:6]1[C:11]([C:12]([CH2:14][CH2:15][CH2:16]Cl)=[O:13])=[CH:10][CH:9]=[C:8]([Cl:18])[CH:7]=1>CN(C)C=O>[Cl:18][C:8]1[CH:7]=[CH:6][C:11]([C:12](=[O:13])[CH2:14][CH2:15][CH2:16][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 27237814,4'-Dichlorobutyrophenone

생성물 1

HCID 190783351-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a 0° C. slurry of 10.5 g. of imidazole in 15 ml. dry dimethylformamide was added 6.5 g. of γ,p-dichlorobutyrophenone and the mixture was stirred overnight at room temperature then one day at 60° C. The above solution was poured into 400 ml. of water and extracted three times with ethyl acetate. The combined extracts were washed with water, dried over magnesium sulfate and the solvent evaporated to afford 1-[4-(4-chlorophenyl)butan-4-onyl]imidazole, which was used in the next step. This material may be further purified, if necessary, through the nitrate salt.

후처리

  1. customTo a 0° C.
  2. customone day
  3. customat 60° C
  4. additionThe above solution was poured into 400 ml
  5. extractionof water and extracted three times with ethyl acetate
  6. washThe combined extracts were washed with water
  7. dry with materialdried over magnesium sulfate
  8. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-8638fe06652943ee8f370931966af829
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045568

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