Dimethylformamide → Octyl 4'-hydroxy-4-biphenylcarboxylate

HRID 442597

반응식

HRID 442597 반응식
FC(F)(F)[CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].CN(C)[CH:15]=[O:16].[CH2:18](N(CC)CC)[CH3:19].[CH:25]1[C:34]2[C:29](=[CH:30][C:31]([C:35](Cl)=[O:36])=[CH:32][CH:33]=2)C=C[C:26]=1[C:38](Cl)=O.[CH2:41](Cl)Cl>>[CH2:3]([O:10][C:35]([C:31]1[CH:32]=[CH:33][C:34]([C:25]2[CH:26]=[CH:38][C:15]([OH:16])=[CH:19][CH:18]=2)=[CH:29][CH:30]=1)=[O:36])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:41]

참가 물질

6

반응물 5

HCID 6228DimethylformamideHCID 6344Dichloromethane2회HCID 8471TriethylamineHCID 978042-Octanol, 1,1,1-trifluoro-HCID 34855962,6-Naphthalenedicarbonyl dichloride

생성물 1

HCID 14692993Octyl 4'-hydroxy-4-biphenylcarboxylate

실험 절차

Optically active 1,1,1-trifluoro-2-octanol (0.3 g), dimethylformamide (0.2 g) and triethylamine (0.18 g) were dissolved in methylene chloride (20 ml). To this solution was added in small portions a solution of 2,6-naphthalenedicarboxylic acid dichloride (0.8 g) obtained in the step 2) of Example 7 in methylene chloride (50 ml) under ice-cooling, and the mixture was stirred for about 20 hours. Next, 4-n-octyloxycarbonyl-4'-hydroxybiphenyl (0.55 g) obtained in the step 1) was dissolved in methylene chloride (30 ml) and added in small portions to the reaction mixture. The resulting mixture was stirred for about 20 hours.

후처리

  1. temperaturecooling

출처 및 근거

ORD 기록
ord-401bdc46047c4f3aa69c17a8d3cd0a1a
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891359

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