Sodium Cyanide → Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

HRID 44260노트

반응식

HRID 44260 반응식
[I-].[CH2:2]([O:4][C:5]([C:7]1[NH:11][CH:10]=[C:9]([CH2:12][N+](C)(C)C)[CH:8]=1)=[O:6])[CH3:3].[C-:17]#[N:18].[Na+]>C(O)C>[C:17]([CH2:12][C:9]1[CH:8]=[C:7]([C:5]([O:4][CH2:2][CH3:3])=[O:6])[NH:11][CH:10]=1)#[N:18]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 86662429[5-(Ethoxycarbonyl)-1H-pyrrol-3-yl]-N,N,N-trimethyl-methanaminium iodide

생성물 1

HCID 66636709Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of the product obtained in Step E and sodium cyanide (0.225 g) in ethanol is heated at reflux for 72 hours. After evaporation to dryness, the residue is taken up in a mixture of CH2Cl2/water. The aqueous phase is extracted three times with CH2Cl2. The organic phases are combined. The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product which is used directly in the next Step.

후처리

  1. temperatureat reflux for 72 hours
  2. customAfter evaporation to dryness
  3. additionthe residue is taken up in a mixture of CH2Cl2/water
  4. extractionThe aqueous phase is extracted three times with CH2Cl2
  5. dry with materialThe organic phase is dried over magnesium sulphate
  6. filtrationfiltered
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f8f6b8b94a644047af8b878ba8382a83
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

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