{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol → 4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

HRID 44264노트

반응식

HRID 44264 반응식
[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH2:13][OH:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>C1COCC1.O=[Mn]=O>[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH:13]=[O:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 66636497{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol

생성물 1

HCID 866508254-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the product obtained in Step I (0.09 g) in THF (3.8 ml) there is added activated MnO2 (0.315 g). After stirring for 20 hours at ambient temperature, the mixture is filtered and the filtrate is evaporated to dryness to yield the title product, which is used directly in the next step.

후처리

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness

출처 및 근거

ORD 기록
ord-149fe9fcd74f4f9198e7139940144834
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

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