Imidazole → Tert-butyloxycarbonylimidazole

HRID 4427

반응식

HRID 4427 반응식
[C:1](=[O:14])(OC(Cl)C(Cl)(Cl)Cl)[O:2][C:3]([CH3:6])([CH3:5])[CH3:4].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>C1COCC1>[C:3]([O:2][C:1]([C:16]1[NH:15][CH:19]=[CH:18][N:17]=1)=[O:14])([CH3:4])([CH3:5])[CH3:6]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 2724535Tert-butyl 1,2,2,2-tetrachloroethyl Carbonate

생성물 1

HCID 22359409Tert-butyloxycarbonylimidazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
20 °C

실험 절차

5 g (17.5 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate dissolved in 10 ml of THF are added at 0° C. to a solution of imidazole (1.2 g; 17.6 mmol) in THF (20 ml) in the presence of 5M aqueous potassium carbonate solution (5 ml). The mixture is stirred for 1 hour at 20° C., and the organic phase is decanted and washed with 10 ml of saturated aqueous NaCl solution.

후처리

  1. customthe organic phase is decanted
  2. washwashed with 10 ml of saturated aqueous NaCl solution

출처 및 근거

ORD 기록
ord-18ed9719ba5540d59af2fe55eab3dddb
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725680

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