Triphenylphosphine → 3-(3-Acetamidophenylethynyl)-3-(3-cyclopentyloxy-4-methoxyphenyl)-cyclohexan-1-one

참여 물질

역할	이름	HCID	투입량
반응물	Triphenylphosphine	HCID 11776	—
반응물	3'-Iodoacetanilide	HCID 87971	—
반응물	3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-ethynylcyclohexan-1-one	HCID 15392007	—
촉매	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
촉매	HCID 178418397	HCID 178418397	—
용매	Triethylamine	HCID 8471	—
생성물	3-(3-Acetamidophenylethynyl)-3-(3-cyclopentyloxy-4-methoxyphenyl)-cyclohexan-1-one	HCID 15859060	60%

반응 조건

온도	80 °C

반응 단계

To a solution of the compound from Example 3 (E1) (0.2 g, 0.64 mmol) and 3-acetamido-1-iodobenzene (0.17 g, 0.64 mmol) in triethylamine (5 mL) under an argon atmosphere was added trace tetrakis(triphenylphosphine)palladium(0), copper(I) iodide and triphenylphosphine. The mixture was heated at 80° C. for 0.3 h, was cooled to room temperature and was concentrated in vacuo. The residue was purified by flash chromatography, eluting with 1:1 hexanes/ethyl acetate, to provide the title compound as tan solid (0.17 g, 60%), m.p. 58°-60° C.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05891883
출처 데이터셋	uspto-grants-1999_04
ORD ID	ord-108349e34c914da5977b248d087fe4ae
출처 메모	uspto-grants-1999_04