Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 442711생성일: 2026년 10월 26일
Triphenylphosphine → 3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-(3-methanesulfonamidophenylethynyl)cyclohexan-1-one
https://huagongshe.com/reaction/442711
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-ethynylcyclohexan-1-one | HCID 15392007 | — |
| 반응물 | N-(3-iodophenyl)methanesulfonamide | HCID 21830928 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-(3-methanesulfonamidophenylethynyl)cyclohexan-1-one | HCID 21830934 | 58.4% |
반응 단계
To a solution of the compound from Example 3 (E1) (0.2 g, 0.64 mmol) and 1-iodo-3-methanesulfonamidobenzene (0.19 g, 0.64 mmol) in triethylamine (5 mL) under an argon atmosphere was added trace tetrakis(triphenylphosphine)palladium(0), copper(I) iodide and triphenylphosphine. The mixture was heated at 80° C. for 0.3 h, was cooled to room temperature and was concentrated in vacuo. The residue was purified by flash chromatography, eluting with 1:1 hexanes/ethyl acetate, to provide the title compound as a tan solid (0.18 g, 58%), m.p. 59°-62° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05891883 |
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| 출처 데이터셋 | uspto-grants-1999_04 |
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| ORD ID | ord-c45e7ddba5fe4c299ff44815d0eee6f6 |
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| 출처 메모 | uspto-grants-1999_04 |
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