참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 6-Methylindole-3-carboxaldehyde | HCID 4777902 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1,6-Dimethyl-1H-indole-3-carbaldehyde | HCID 22593746 | 97% |
반응 단계
A solution of the known 6-methyl-1H-indole-3-carboxaldehyde (5 g, 31 mm) in DMF (100 mL) was cooled to 0° C. and treated with NaH (38 mm), and stirred at 0° C. for 3 hours. After treatment with CH3I (2.35 mL, 38 mm), the mixture was allowed to warm to room temperature overnight. The mixture was poured into H2O(500 mL) and extracted with ethylacetate (EtOAc) (200 mL×3). The combined organic layers were dried over MgSO4, filtered and evaporated. Purification by flash column chromatography afforded 1,6-dimethyl-1H-indole-3-carboxaldehyde (5.2 g, 97%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05891901 |
|---|
| 출처 데이터셋 | uspto-grants-1999_04 |
|---|
| ORD ID | ord-56cb28cf919340c083e1a725acc2a2fc |
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| 출처 메모 | uspto-grants-1999_04 |
|---|
