Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Monoethyl malonate | HCID 70615 | — |
| 반응물 | Lithium, mol. (Li2) | HCID 139759 | — |
| 반응물 | 4-Bromo-2-methylbenzoyl chloride | HCID 12846483 | — |
| 생성물 | Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate | HCID 53404613 | — |
반응 단계
2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05891899 |
| 출처 데이터셋 | uspto-grants-1999_04 |
| ORD ID | ord-ddc09ecaf6e64ae8b211449d5c77514a |
| 출처 메모 | uspto-grants-1999_04 |