Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

HRID 442797

반응식

HRID 442797 반응식
[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Li][Li].[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15]C(O)=O>>[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([CH2:15][C:14]([O:20][CH2:21][CH3:22])=[O:19])=[O:5]

참가 물질

4

반응물 3

HCID 70615Monoethyl malonateHCID 139759Lithium, mol. (Li2)HCID 128464834-Bromo-2-methylbenzoyl chloride

생성물 1

HCID 53404613Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

실험 절차

2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.

후처리

  1. customthe product was isolated by the procedure
  2. customThe crude product was purified on flash silica
  3. washeluting with dichloromethane-hexane (1:1

출처 및 근거

ORD 기록
ord-ddc09ecaf6e64ae8b211449d5c77514a
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891899

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