p-Chlorophenacyl bromide → 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

HRID 44282

반응식

HRID 44282 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=O.C([O:14][C:15]([NH:17][NH2:18])=[S:16])C>C(#N)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[CH2:2][S:16][C:15](=[O:14])[NH:17][N:18]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 68303p-Chlorophenacyl bromideHCID 12567113O-Ethyl hydrazinecarbothioate

생성물 1

HCID 3294735-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (90.71 mmoles) and hydrazine-carbothioic acid O-ethyl ester (90.71 mmoles) in acetonitrile (84 ml) is stirred at ambient temperature for 3 hours. The solid formed is filtered off, washed with acetonitrile and ethyl ether and then dried in vacuo to yield the title product, which is used directly in the next Step.

후처리

  1. customThe solid formed
  2. filtrationis filtered off
  3. washwashed with acetonitrile and ethyl ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-1ac677b44aaf48988d0fdf72e6301e2f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

연결된 노트

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