참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 반응물 | 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one | HCID 329473 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 66636793 | HCID 66636793 | — |
반응 단계
To a solution of the compound obtained in Step A (57.83 mmoles) in acetonitrile (260 ml) there are added 1-bromomethyl-4-nitro-benzene (63.61 mmoles) and potassium carbonate (231.32 mmoles). The reaction mixture is stirred at 80° C. for 1 hour under nitrogen. The reaction mixture is brought to ambient temperature and 100 ml of water are added. Extraction with ethyl ether (3×350 ml) is carried out and the organic phases are combined. The organic phase obtained is dried over sodium sulphate, filtered and evaporated to dryness. The solid is triturated in ethyl ether, filtered off and dried in vacuo to yield the title product, which is used directly in the next Step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541412B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-02652757b88b4162a185048b91d42468 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
