4,4'-Difluorobenzhydryl alcohol → N-Isopropyl-3-[bis(4-fluorophenyl)methyl]indole-2-sulfonamide

HRID 442875

반응식

HRID 442875 반응식
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6](O)[C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH:17]([NH:20][S:21]([C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2)(=[O:23])=[O:22])([CH3:19])[CH3:18]>>[CH:17]([NH:20][S:21]([C:24]1[NH:25][C:26]2[C:31]([C:32]=1[CH:6]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[C:5]1[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2)(=[O:23])=[O:22])([CH3:19])[CH3:18]

참가 물질

3

반응물 2

HCID 1230494,4'-Difluorobenzhydryl alcoholHCID 54122335N-isopropylindole-2-sulfonamide

생성물 1

HCID 67595589N-Isopropyl-3-[bis(4-fluorophenyl)methyl]indole-2-sulfonamide수율 80%

실험 절차

Substantially the same procedure as in Example 266 was repeated using 4,4'-difluorobenzhydrol (0.99 g, 4.50 mmol) and N-isopropylindole-2-sulfonamide (1.00 g, 4.46 mmol) to give 1.56 g (yield: 80%) of the title compound.

출처 및 근거

ORD 기록
ord-e3974e13e19d48069c8ea0859610e2d1
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891902

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