Ethyl indole-2-carboxylate → Ethyl 3-(4-benzyloxybenzhydryl)indole-2-carboxylate

반응식

[CH2:1]([O:8][C:9]1[CH:22]=[CH:21][C:12]([CH:13](O)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[C:24]1[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH2:1]([O:8][C:9]1[CH:22]=[CH:21][C:12]([CH:13]([C:25]2[C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[NH:23][C:24]=2[C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 73125Ethyl indole-2-carboxylate

HCID 105895804-Benzyloxybenzhydrol

생성물 1

HCID 54508530Ethyl 3-(4-benzyloxybenzhydryl)indole-2-carboxylate수율 95%

실험 절차

Substantially the same procedure as in Reference Example 4 was repeated using 4-benzyloxybenzhydrol (30.0 g, 103 mmol) and ethyl indole-2-carboxylate (18.5 g, 97.9 mmol) to give 42.7 g (yield: 95%) of the title compound.

출처 및 근거

ORD 기록: ord-0529c54903954bfd8c50eca480c339c6
출처 데이터셋: uspto-grants-1999_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05891902

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