3-Chloro-1-phenylisoquinoline-4-carbaldehyde → HCID 14567249, 화합물

HRID 443384노트

반응식

HRID 443384 반응식
[Cl:1][C:2]1[N:3]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]2[C:10]([C:11]=1[CH:12]=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.B.[Na]>CO>[Cl:1][C:2]1[N:3]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]2[C:10]([C:11]=1[CH2:12][OH:13])=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

4

반응물 2

HCID 145672483-Chloro-1-phenylisoquinoline-4-carbaldehydeHCID 178418435HCID 178418435, 화합물

생성물 1

HCID 14567249HCID 14567249, 화합물수율 88.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 8.1 g 3-Chloro-1-phenyl-isoquinoline-4-aldehyde in 150 ml methanol there are added portionwise 1.8 g sodium boron hydride at 0° C. The solution is stirred at room temperature for 4 hours and the solvent is removed in vacuo. The residue is stirred with water. Filtration of the resulting mixture gives 7.2 g 3-chloro-4-hydroxymethyl-1-phenyl-isoquinoline having a melting point from 175° to 182° C.

후처리

  1. customthe solvent is removed in vacuo
  2. stirringThe residue is stirred with water
  3. filtrationFiltration of the resulting mixture

출처 및 근거

ORD 기록
ord-c4af0db51f7a4986ab520ade569d2131
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260611

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