Benzoyl isocyanate → N-(2-Cyano-3-methylphenylcarbamoyl)benzamide

반응식

[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[C:4]#[N:5].[C:11]([N:19]=[C:20]=[O:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:4]([C:3]1[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:2]=1[NH:1][C:20]([NH:19][C:11](=[O:18])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:21])#[N:5]

참가 물질

반응물 2

HCID 78210Benzoyl isocyanate

HCID 2799732-Amino-6-methylbenzonitrile

생성물 1

HCID 57456903N-(2-Cyano-3-methylphenylcarbamoyl)benzamide

실험 절차

Prepared as in example 1a from 2-amino-6-methylbenzonitrile and benzoyl isocyanate as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ7.19 (d, J=7.6 Hz, 1H), 7.52-7.68 (m, 5H), 8.02-8.08 (m, 2H), 11.32 (s, 1H), 11.46 (s, 1H). MS 280 (MH+).

출처 및 근거

ORD 기록: ord-47c2cda10fb849058b8f40ec35f31c2f
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08541421B2

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