2-Aminobenzonitrile → N-(2-Cyanophenylcarbamoyl)benzamide

반응식

[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:10]([N:18]=[C:19]=[O:20])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[NH:1][C:19]([NH:18][C:10](=[O:17])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:20])#[N:5]

참가 물질

반응물 2

HCID 729132-Aminobenzonitrile

HCID 78210Benzoyl isocyanate

생성물 1

HCID 57456910N-(2-Cyanophenylcarbamoyl)benzamide

실험 절차

Prepared as in Example 1a from 2-aminobenzonitrile and benzoyl isocyanate as a white powder (661 mg, 59%). 1H NMR (400 MHz, DMSO-d6) δ7.27-7.29 (t, 1H), 7.52-7.56 (t, 1H), 7.64-7.74 (m, 2H), 7.82-7.85 (dd, 1H), 8.02-8.04 (m, 2H), 8.22-8.24 (d, 1H). MS 266 (MH+).

출처 및 근거

ORD 기록: ord-37a74c890309483ca4c8b876dea92a1d
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08541421B2

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