Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bis(S-methylisothiouronium) sulfate → 2-Guanidinomethyl-indoline hemisulphate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bis(S-methylisothiouronium) sulfate | HCID 13347 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Ethyl Indoline-2-carboxylate | HCID 11949691 | — |
| 반응물 | 1-Benzyl-2-chloromethyl-indoline | HCID 23467351 | — |
| 반응물 | Phthalimide potassium salt | HCID 24194345 | — |
| 반응물 | 1-Benzyl-2-guanidinomethyl-indoline hemisulphate | HCID 178512742 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Guanidinomethyl-indoline hemisulphate | HCID 178512743 | — |
반응 단계
10 g of 1-benzyl-2-guanidinomethyl-indoline hemisulphate (obtainable from ethyl indoline-2-carboxylate by N-benzylation, reduction and reaction with SOCl2 to give 1-benzyl-2-chloromethyl-indoline, reaction of the latter with potassium phthalimide and hydrolysis of the reaction product, and reaction of this product with S-methyl-isothiourea hemisulphate) are dissolved in 200 ml of ethanol and hydrogenated over 3 g of 5% Pd/C at 20° C. and 1 atmosphere until the reaction ceases. After filtering and evaporating the filtrate, 2-guanidinomethyl-indoline hemisulphate is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04260628 |
| 출처 데이터셋 | uspto-grants-1981_04 |
| ORD ID | ord-fba2e1b2f2a44d9c9008b938e3f3152c |
| 출처 메모 | uspto-grants-1981_04 |