Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | 2-Amino-4,5-dimethyl-thiophene-3-carbonitrile | HCID 290236 | — |
| 반응물 | Cyano-borohydride | HCID 498716 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile | HCID 319451 | — |
반응 단계
To a solution of 2-amino-4,5-dimethylthiophene-3-carbonitrile (151 mg, 1.0 mmol) and benzaldehyde (106 mg, 1 mmol) in 15 mL of 4% acetic acid in dichloroethane was added silica supported cyanoborohydride (2.0 g. 2.0 mmol). The reaction was placed in a microwave reactor for 5 minutes at 135° C. Silica supported cyanoborohydride was removed by filtration, and the product was purified by prep HPLC using acetonitrile/water as solvent. MS 243 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541421B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-77eaccefdd3b4e7e9282a9c89df827f7 |
| 출처 메모 | uspto-grants-2013_09 |