Water → Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)-

HRID 443621노트

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HRID 443621 반응식
C[Li].[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH:17]=[C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=1)[C:14](O)=O)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O1CCC[CH2:29]1.[OH2:33]>CCOCC>[CH3:29][C:14]([C:13]1[CH:12]=[C:11]([O:10][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:19]=[C:18]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:17]=1)=[O:33]

참가 물질

6

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 993073,5-Bis(phenylmethoxy)benzoic acidHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 120098Ethanone, 1-(3,5-bis(phenylmethoxy)phenyl)-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Over a period of 1.5 hours, methyl lithium (531 ml. of a 2 molar solution, 1.06 M) is added under a nitrogen atmosphere to a rapidly stirring solution of 3,5-dibenzyloxybenzoic acid (175 g., 0.532 M) in ether (250 ml.)tetrahydrofuran (1400 ml.) maintained at 15°-20° C. After stirring an additional 0.75 hour at 10°-15° C., water (600 ml.) is slowly added keeping the reaction temperature below 20° C. The aqueous layer is separated and extracted with ether (3×250 ml.). The organic phases are combined, washed with saturated sodium chloride solution (4×300 ml.), dried over sodium sulfate, and concentrated under vacuum to give an oil which slowly crystallized from isopropyl ether. The crude product is recrystallized from ether-hexane to yield 104.7 g. (59%) of product; m.p. 59°-61° C.

후처리

  1. temperaturemaintained at 15°-20° C
  2. customthe reaction temperature below 20° C
  3. customThe aqueous layer is separated
  4. extractionextracted with ether (3×250 ml.)
  5. washwashed with saturated sodium chloride solution (4×300 ml.)
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under vacuum
  8. customto give an oil which
  9. customslowly crystallized from isopropyl ether
  10. customThe crude product is recrystallized from ether-hexane
  11. customto yield 104.7 g

출처 및 근거

ORD 기록
ord-ccf04535a786492793e0db1593e71e30
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260764

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